WELCOME
Innovative Research Lab
We are Ghezzi Lab Behavioral Genetics and Neuroscience , an interdisciplinary Research Lab based in San Juan, Puerto Rico. We investigate novel concepts that underlie the complexities of our field.
Dr. Alfredo Ghezzi, PhD
In the Ghezzi Lab, we are interested on the molecular basis of neural adaptation. Through the integration of molecular genomics, behavioral analyses, and neurophysiology, we strive to resolve how the nervous system utilizes a finite number of genes to carefully modulate neural activity and adapt to an ever-changing environment. A central component of this effort is directed to understanding the mechanisms of transcriptional memory that perpetuate drug-induced adaptations and promote addiction. Students in the lab combine the powerful Drosophila genetic model and a range of genomic and neurophysiological techniques to identify and categorize epigenetic regulatory mechanisms.
About us:
Our model subject
Drosophila melanogaster
The Drosophila melanogaster is used in our lab as the model organism. It is the most suitable species for our objective; for we in Ghezzi lab aspire to study phenotypes, specific traits, diseases, and behavior similar to human. By having approximately 60% of their genome homologous to that of humans we are able to study diseases such as epilepsy, cancer, alcohol intolerance and many other. In addition, having a karyotype of only 4 chromosomes facilitates genetic manipulation that grants us the ability to implement biochemical methods such as UAS/GAL-4. Their short life span gives us the advantage to create a larger population in a shorter period of time and with their small size they are easier to handle, occupying little space and requiring smaller dosages of anesthesia. Rendering our materials to last longer and be more budget friendly. Since they are easy to maintain because of their survival conditions, they can be kept at room temperature, be stored in vials or bottles, fed on an easily prepared cornmeal-like substance that last 5 days and be disposed of in mineral oil without any complications. Generating satisfying results with the same quality and work ethic.
RESEARCH
Primary Areas of Interest
NEUROSCIENCE
Neuroscience also known as neural science is a subdivision of biology that seeks to study the nervous system development, function and behavior.
BEHAVIORAL GENETICS
Behavioral genetics is the study of genetic and eviromental influences on behavior.
EPIGENETICS
Epigenetic involves genetic control and is study of how your behaviors and environment can cause changes that effect the way your genes work.
CONTACT US
Universidad de Puerto Rico, Río Piedras 14 Ave. Universidad STE 1401
Julio García Díaz Bldg., 203 San Juan PR, 00931
(787) 764-0000; ext. 88137